Is Vyleesi Covered by Insurance? – A Comprehensive Guide

Many individuals with sexual dysfunction issues seek treatment options to enhance their quality of life. Vyleesi, a medication also known as bremelanotide, has gained attention as a potential solution for low sexual desire in premenopausal women. However, one common concern among patients is whether Vyleesi is covered by insurance. In this comprehensive guide, we will delve into the coverage aspects of Vyleesi, explore alternative treatment options, and address frequently asked questions related to insurance coverage.

What is it and How Does it Work?

Vyleesi is an injectable medication approved by the U.S. Food and Drug Administration (FDA) for the treatment of acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women. HSDD refers to a persistent lack of sexual desire that causes distress in women, and Vyleesi aims to address this condition.

Vyleesi acts on the melanocortin receptors in the brain, enhancing sexual desire and reducing distress related to low libido. It is intended for use in women who have not yet gone through menopause and who experience low sexual desire that is not attributable to any medical or psychiatric condition, relationship problems, or the use of medications or substances.

Who Can Benefit from Vyleesi?

Vyleesi is specifically designed for premenopausal women who suffer from HSDD. This condition is characterized by a persistent lack of sexual desire that causes significant distress and cannot be attributed to other factors, such as relationship issues or medical conditions

Insurance Coverage for Vyleesi

When it comes to insurance coverage for Vyleesi, the situation can be complex and dependent on several factors, including the individual insurance plan and the specific medical condition. Here are some key points to consider:

  1. Vyleesi is a relatively new medication, and insurance coverage may vary among different providers and plans. It is important to review your specific insurance policy or contact your insurance provider directly to determine coverage options.
  2. Some insurance plans may cover Vyleesi under certain conditions, such as a prior authorization requirement or proof of medical necessity. This means that your healthcare provider needs to submit documentation justifying the need for Vyleesi based on your specific condition.
  3. Patient assistance programs may be available to help reduce the out-of-pocket costs associated with Vyleesi. These programs can provide financial assistance or copay savings for eligible patients. Your healthcare provider or the manufacturer of Vyleesi can provide more information about these programs.
  4. It is essential to keep in mind that insurance coverage can change over time, so it is always recommended to check with your insurance provider to get the most up-to-date information about coverage for Vyleesi.
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Coverage by Major Insurance Providers

To give you a general idea of insurance coverage for Vyleesi, here’s a quick rundown of some major insurance providers:

  1. Aetna: Coverage for Vyleesi may be available under certain Aetna plans, but it’s important to check your specific plan details or contact Aetna directly for more information[source].
  2. Cigna: As of July 2021, Cigna has added Vyleesi to its formulary, making it available for coverage under certain plans[source].
  3. UnitedHealthcare: Coverage for Vyleesi may be available under some UnitedHealthcare plans, but it’s essential to verify your specific plan details or contact UnitedHealthcare directly for more information[source].

Keep in mind that this list is not exhaustive, and coverage can vary between different plans and providers. It’s always best to check with your insurance provider directly to determine if Vyleesi is covered under your specific plan.

Alternative Treatment Options

If Vyleesi is not covered by your insurance or if you are looking for alternative treatment options, there are other approaches to consider. Here are a few alternatives that you can discuss with your healthcare provider:

  1. Behavioral Therapy: Psychological counseling or therapy can help address underlying emotional or psychological factors contributing to low sexual desire.
  2. Hormone Therapy: Depending on the specific hormonalimbalances, hormone therapy may be an effective option. This approach involves the use of medications or hormone replacement therapies to restore hormonal balance and enhance sexual desire.
  3. Alternative Medications: Other medications, such as flibanserin (Addyi), may be prescribed as an alternative to Vyleesi. These medications work differently but can also help improve sexual desire in premenopausal women.
  4. Lifestyle Changes: Incorporating healthy lifestyle habits, such as regular exercise, stress reduction techniques, and open communication with your partner, can positively impact sexual desire and overall well-being.
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Frequently Asked Questions about Vyleesi Coverage

1. Is Vyleesi covered by all insurance plans?

No, coverage for Vyleesi varies depending on the insurance plan. It is recommended to review your specific policy or contact your insurance provider to determine coverage options.

2. How can I find out if my insurance covers Vyleesi?

To find out if your insurance covers Vyleesi, you can:

  • Contact your insurance provider directly and inquire about coverage for Vyleesi.
  • Review your insurance policy documents for information regarding coverage of prescription medications.
  • Consult with your healthcare provider, who can assist in determining coverage options and possibly provide alternatives if needed.

3. What should I do if Vyleesi is not covered by my insurance?

If Vyleesi is not covered by your insurance, consider the following steps:

  • Discuss alternative treatment options with your healthcare provider.
  • Inquire about patient assistance programs or copay savings offered by Vyleesi’s manufacturer.
  • Explore other medications approved for treating low sexual desire in premenopausal women.

4. Can my healthcare provider help with insurance coverage for Vyleesi?

Yes, your healthcare provider can assist you with insurance coverage for Vyleesi. They can provide the necessary documentation and information required by your insurance company to justify the medical necessity of Vyleesi.

5. Are there any side effects of Vyleesi?

Yes, Vyleesi may cause side effects. The most common side effects include nausea, flushing, injection site reactions, and headache. It is important to discuss any concerns or potential side effects with your healthcare provider before starting Vyleesi.


In conclusion, the coverage of Vyleesi by insurance can vary depending on the specific insurance plan and individual circumstances. It is advisable to review your insurance policy or consult your insurance provider to determine the coverage options for Vyleesi. Alternatively, discussing alternative treatment options with your healthcare provider and exploring patient assistance programs or copay savings can be beneficial. Remember, the ultimate goal is to find the most suitable treatment option for enhancing sexual desire and improving your quality of life.